Canadian Medical Association

Last updated: August 4, 2022

CMA members have access to skilled medical librarians. Our team of librarians can support you by searching on your behalf, teaching you effective search strategies or training you to use our resources. Get the latest evidence and save time, so you can focus on what’s important to you.

CMA Joule’s Ask a Librarian team is committed to curating free evidence-based resources related to the COVID-19 pandemic. We continue to update the Ask a Librarian: COVID-19  and the Ask a Librarian: COVID-19 vaccines and the immunization roll-out posts with current clinical summaries, article collections, guidance and more.

Here we focus on information sources specific to post‒COVID-19 condition — also known as long COVID, long-haul COVID, post-acute COVID-19 (PACS), post-acute sequelae of COVID-19 (PASC), long-term effects of COVID, or chronic COVID. On October 6, 2021 the World Health Organization (WHO) published a clinical case definition based on Delphi methodology that was developed in consultation with hundreds of patients, researchers, external experts and WHO staff. The standardized definition includes 12 domains to help clinicians in all settings identify patients more easily and to advance recognition and research:

Post COVID-19 condition occurs in individuals with a history of probable or confirmed SARS CoV-2 infection, usually 3 months from the onset of COVID-19 with symptoms and that last for at least 2 months and cannot be explained by an alternative diagnosis. Common symptoms include fatigue, shortness of breath, cognitive dysfunction but also others and generally have an impact on everyday functioning. Symptoms may be new onset following initial recovery from an acute COVID-19 episode or persist from the initial illness. Symptoms may also fluctuate or relapse over time.

Clinical summaries

DynaMed

(Included with membership. Access now)  – COVID-19 (Novel Coronavirus) – see Post-acute COVID-19 Syndrome (PACS) in Complications section. 

BMJ Best Practice

Coronavirus Disease (COVID-19). Under “Complications” see “post COVID-19 syndrome”. 

UptoDate

COVID-19: Evaluation and management of adults following acute viral illness. ("Long COVID").


Evidence reviews

American Family Physician

Coronavirus Disease 2019 (COVID-19) Daily Research Briefs. Search "long COVID" and/or other synonyms.

Canadian Agency for Drugs and Technology in Health (CADTH)

An Overview of Post‒COVID-19 Condition (Long COVID). September 24, 2021.

Post‒COVID-19 Condition: A Condition-Level Review. September 14, 2021

COVID-19 Evidence Synthesis Network

Evidence Synthesis Briefing Note: The Assessment and Treatment of Post-COVID-19 Condition. April 11, 2022.

Evidence Synthesis Briefing Note: Understanding The Post-COVID Condition. April 1, 2022.

McMaster University

COVID-END – Care Models for Long COVID - A Rapid Systematic Review. May 27, 2021.

COVID-19 Evidence Alerts – weekly update of high-quality clinical studies with free email notifications. Search “long COVID” and/or other synonyms.


Articles and article collections

CMAJ articles

The evolving picture of long COVID. Diana Duong. CMAJ Jun 2022, 194 (24) E850-E851; DOI: 10.1503/cmaj.1096004

Unpacking “long COVID”. Terry Murray. CMAJ March 01, 2021 193 (9) E318-E319; DOI: https://doi.org/10.1503/cmaj.1095923

Even mild COVID-19 may have long-term brain impacts. Diana Duong. CMAJ August 30, 2021 193 (34) E1360-E1361; DOI: https://doi.org/10.1503/cmaj.1095958


Guidelines and other information

International

Centers for Disease Control and Prevention – Post-COVID Conditions: Information for Healthcare Providers

Centers for Disease Control and Prevention – Evaluating and Caring for Patients with Post-COVID Conditions: Interim Guidance

National Institute for Health and Care Excellence (NICE) – COVID-19 rapid guideline: managing the long-term effects of COVID-19

World Health Organization – A clinical case definition of post COVID-19 condition by a Delphi consensus

World Health Organization – Post COVID-19 condition (Long COVID)

National

CMA Joule – CPG Infobase: Clinical Practice Guidelines on Long COVID

Center for Effective Practice – COVID-19: Clinical Guidance for Primary Care Providers - Long-term symptoms / Post-acute sequelae of COVID-19 (PASC)

Government of Canada – COVID-19 for health professionals: Post COVID-19 condition

Viral Neuro Exploration, COVID Long Haulers Support Group Canada, and Neurological Health Charities Canada – Report on Pan-Canadian Long Covid Impact Survey. June 8, 2021.

Provincial

British Columbia

Provincial Health Services Authority – Post-COVID-19 Care

Alberta

Alberta Health Services – Recovery & Rehabilitation After COVID-19: Resources for Health Professionals

Saskatchewan

Saskatchewan Health Authority – Long-COVID information repository to support Saskatchewan decision-makers during the COVID pandemic. 

Ontario

Ontario COVID-19 Science Advisory Table – Understanding the Post COVID-19 Condition (Long COVID) and the Expected Burden for Ontario

Nova Scotia

Nova Scotia Health. My COVID Recovery – your source of health information after having COVID-19


Patient information

CanCov – Patient resources to help people cope with the disease. 

Government of Canada – Post COVID-19 condition. .

Johns Hopkins Medicine – COVID ‘Long Haulers’: Long-Term Effects of COVID-19

Long Covid Canada. Includes Long COVID information, patient stories and provincial supports. 

Mayo Clinic – COVID-19 (coronavirus): Long-term effects

University Health Network. Health Science Information Consortium of Toronto. Long COVID: COVID-19 Resources for Patients and Families


Long COVID search in PubMed

Long COVID search – LitCovid is a curated literature hub for tracking current scientific information about the 2019 novel Coronavirus. Updated daily.

Long COVID search – COVID-19 Portfolio - NIH’s comprehensive, expert-curated source for publications and preprints related to COVID-19 and the novel coronavirus SARS-CoV-2.


Need more information or have a more focused clinical question on Post‒COVID-19 Condition or any other clinical topic of interest? Contact the Ask a Librarian team to request a literature search.


This material is for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. The opinions stated by the authors are made in a personal capacity and do not necessarily reflect those of the Canadian Medical Association and its subsidiaries including CMA Joule.

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